Worldwide, researchers and industry leaders are improving health outcomes for patients by utilizing the multi-functional efficacy of regulatory t cells to develop novel therapies and disease treatments. Regulatory T cells, commonly referred to as ‘T-regs’, play a critical role in maintaining order in the human immune system by regulating and suppressing excessive inflammation. Given the therapeutic potential of T-regs for patients with autoimmune diseases, cancer, and organ transplants, both researchers and industry leaders are developing novel therapies that utilize the multi-functional efficacy of T-reg cells in disease treatments to improve health outcomes for patients.
Posted By Marcus Curl on 5/14/19 1:20 PM
Cellastim S Recombinant Human Serum Albumin in the Generation of Functional Cardiomyocytes from Pluripotent Stem Cells
Posted By Jeanne McAdara Ph.D. on 5/9/19 11:00 AM
The number and breadth of applications for induced human embryonic and pluripotent stem cells (hi-ESCs and hi-PSCs) in both research and clinical settings continue to co-evolve with our understanding of how to harness them as biological tools.
Posted By Attie Pennybaker on 5/7/19 9:00 AM
The American Society of Gene & Cell Therapy (ASGCT) held their 22nd annual meeting in Washington D.C. last week from April 29th through May 2nd bringing together a record number of over 3,400 attendees to share and discuss the remarkable work going on to advance this field. With 23 Scientific Symposia and 1000 abstracts presented through talks and poster sessions over the course of the conference, there was no shortage of knowledge to be shared.
Posted By Jeanne McAdara Ph.D. on 4/16/19 2:00 PM
Enhanced liquid-phase stability of live-attenuated Flavivirus vaccines using recombinant albumin
The single-stranded RNA viruses belonging to the genus Flavivirus (family, Flaviviridae) are significant to global public health due to the high rates of morbidity and mortality they cause.1 For example, Yellow Fever sickens approximately 200,000 people and kills 30,000 annually.2 Other viruses belonging to this genus include the mosquito-borne diseases Dengue Fever, Japanese encephalitis, West Nile virus, and Zika virus, and the tick-borne diseases Tick-borne Encephalitis, Kyasanur Forest Disease, Alkhurma disease, and Omsk hemorrhagic fever.
Virus production is an important application of cell culture systems, both for vaccine manufacturing as well as for gene therapy. During the cell culture process, the infectious particles produced are subjected to several physical stresses inherent to the cell culture system that may cause inactivation and reduce the overall productivity of the culture.Here, a general protocol is described for the addition of recombinant albumin, in the form of the product Cellastim S, to virus production systems to stabilize infectious particles and thereby maximize viral yield.